Rheumatic diseases characterized by high levels of inflammatory cytokines, such as interferon‐gamma (IFN‐γ) and tumor necrosis factor‐alpha (TNF‐α) which stimulate MSCs to produce various kinds of cytokines, such as hepatocyte growth factor (HGF) and transforming growth factor‐beta (TGF‐β), soluble factors like PGE2, indoleamine‐2,3‐dioxygenase (IDO), and nitric oxide (NO). The gene discussed is HGF; the disease is rheumatic disorder.