FTO and obesity due to melanocortin 4 receptor deficiency: Like FTO, MC4R is also associated with food intake requirements and energy balance within the body.56 In 2008, a GWAS reported a strong association between the SNP rs17782313 and obesity risk in European populations.56,67 A recent meta-analysis investigated the association of this polymorphism with cancer incidence and revealed that it was moderately associated without BMI adjustment.