Like FTO, MC4R is also associated with food intake requirements and energy balance within the body.56 In 2008, a GWAS reported a strong association between the SNP rs17782313 and obesity risk in European populations.56,67 A recent meta-analysis investigated the association of this polymorphism with cancer incidence and revealed that it was moderately associated without BMI adjustment. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.