Additionally, overexpression of mmu-circ_0081343 upregulated Beclin1 expression, increased the LC3II/I ratio, and downregulated P62 expression, while suppressing the PI3 K/AKT/HIF-1α pathway.<h4>Conclusions</h4>circ_0081343 alleviated gestational hypoxia-induced placental dysfunction and fetal growth restriction (FGR) by promoting autophagy and inhibiting pyroptosis, potentially through the PI3 K/AKT/HIF-1α pathway. Here, HIF1A is linked to fetal growth restriction.