Piperlongumine (PL) constituent of the fruit of Piper longum, inhibits the proliferation of cancer via activation of extrinsic and intrinsic pathways and initiating the imbalance between pro- apoptotic (Bax, Bid, Bad, Bic, Bak, Bok, Bcl-xs, and Hrk) and anti-apoptotic proteins (Bcl-2, Bcl-xl, Bcl-w, A1 and Mcl-1) to promote cell death [7]. This evidence concerns the gene BAK1 and cancer.