Our findings indicate that PL exhibits cancer cells death and antiproliferative effects (Fig. 10), induces nuclear condensation (Fig. 11), decreases mitochondrial membrane potential (Fig. 12), triggers reactive oxygen species (ROS) production (Fig. 13), and causes cell cycle arrest at the G2/M phase (Fig. 14) upregulation of Bax and Bak along with the down regulation of Bcl2 (Fig. 15). Here, BAK1 is linked to cancer.