For instance, Bifidobacterium CCFM683 has been shown to alleviate psoriasis in a dose-dependent manner by restoring the microbiota, regulating the FXR/NF-κB pathway, reducing pro-inflammatory cytokines, modulating keratinocytes, and maintaining epidermal barrier function (Miyazaki et al., 2014; Chen et al., 2023). Here, NR1H4 is linked to psoriasis.