Importantly, HCMV infection of the TMCs has been shown to upregulate IL-8 and CCL2 which then alters the cytoskeletal dynamics and increases the outflow resistance resulting in an elevation of the IOP (Li et al., 2012; Chono et al., 2018; Lee et al., 2021). The gene discussed is CXCL8; the disease is cytomegalovirus infection.