In POAG, IL-6, IL-8, IL-12, IFN-γ, TNF-α, and CXCL9 have been shown to be elevated (Chua et al., 2012; Ghanem et al., 2011; Kuchtey et al., 2010; Sawada et al., 2010). This evidence concerns the gene CXCL9 and open-angle glaucoma.