PANX2 and sensorineural hearing loss disorder: Furthermore, immune infiltration analysis reveals significant correlations between FRGs (e.g., MEF2C with NK cells, PANX2 with M1 macrophages) and pro-inflammatory subsets, suggesting that ferroptosis may amplify cochlear inflammation—a known driver of sensorineural hearing loss (Zhang et al., 2020; Grayson et al., 2022).