Recently, Zhao and colleagues discovered a correlation between AKR1C2 and the onset of Alzheimer’s disease through bioinformatics analysis, considering that TBI is a significant risk factor for Alzheimer’s, this finding provides new clues for further research into the potential mechanisms between TBI and AKR1C2 (Zhao et al., 2023). The gene discussed is AKR1C2; the disease is early-onset autosomal dominant Alzheimer disease.