The immune suppression in TME arises from several mechanisms: 1) Tumor and stromal cells produce factors like transforming growth factor-β (TGF-β), prostaglandin E2 (PGE2), and interleukin-10 (IL-10), which impair the maturation of antigen-presenting cells (APCs) in the TME (95, 96). The gene discussed is IL10; the disease is neoplasm.