TUG1, upregulated by METTL3-mediated m6A modification, promotes immune evasion. TUG1 knockdown inhibits tumor growth and metastasis, enhances CD8+ T cell and M1 macrophage infiltration, activates CD8+ T cells via PD-L1, and promotes macrophage phagocytosis via CD47. TUG1 sequesters miR-141 and miR-340 to regulate PD-L1 and CD47, respectively, and interacts with YBX1 to upregulate their transcription, facilitating immune escape. Here, YBX1 is linked to neoplasm.