The MIR4435-2HG/hsa-miR-1-3p/MMP9/hsa-miR-29-3p/DUXAP8 ceRNA network correlates with tumor stage and invasion depth. MMP9 positively associates with resting M0 macrophages and NK cells but negatively with activated/resting mast cells, monocytes, and activated NK cells. DUXAP8 positively links to M2 macrophages but negatively to MIR4435-2HG, which itself negatively associates with activated mast cells, CD8+ T cells, and follicular helper T cells. The gene discussed is MMP9; the disease is neoplasm.