MIAT in HCC negatively correlates with tumor purity but positively with immune cells (B cells, T lymphocytes, macrophages) and checkpoint molecules (PD-1, PD-L1, CTLA4). MIAT-TF interactions regulate genes (JAK2, SLC6A6, KCND1, MEIS3, RIN1) to influence the immune microenvironment and are linked to sensitivity to anticancer drugs, particularly Sorafenib. This evidence concerns the gene PDCD1 and neoplasm.