Lnc-MA301 is upregulated during M2-to-M1 polarization of U937 macrophages. In HCC, its expression is lower than in adjacent tissues and correlates with poor prognosis. Lnc-MA301 activation inhibits HCC proliferation, migration, EMT, and lung metastasis in mice by interacting with caprin-1 via the Akt/Erk1 pathway. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.