PCED1B-AS1 inhibits PD-Ls expression by sponging hsa-miR-194-5p, inducing PD-Ls-mediated T cell immunosuppression. HCC exosomes containing PCED1B-AS1 enhance PD-Ls in recipient cells while suppressing T cells and macrophages. Blood exosome PCED1B-AS1 correlates with PD-Ls expression in HCC. The gene discussed is PCED1B; the disease is hepatocellular carcinoma.