MEG3 expression rises during LPS/IFN-γ-induced M1 polarization but declines during IL4/IL13-induced M2 polarization. MEG3 overexpression suppresses M2 markers in vitro and in vivo by binding miR-145-5p to upregulate DAB2, inhibiting M2-induced HCC metastasis, angiogenesis, and tumor growth. The gene discussed is IL4; the disease is hepatocellular carcinoma.