miR4458HG promotes HCC proliferation, activates glycolysis, and induces TAM polarization by stabilizing target mRNAs (e.g., HK2, SLC2A1) via IGF2BP2 binding. HCC-secreted miR4458HG exosomes increase ARG1 expression, further driving M2 macrophage polarization. This evidence concerns the gene SLC2A1 and hepatocellular carcinoma.