TGF-β-activated lncRNA-ATB is upregulated in HCC metastasis and linked to poor prognosis. It induces EMT and invasion by sponging miR-200 family, upregulating ZEB1 and ZEB2. lncRNA-ATB also binds IL-11 mRNA, promoting autocrine IL-11 induction and STAT3 activation, enhancing tumor cell colonization. This evidence concerns the gene STAT3 and hepatocellular carcinoma.