MIAT and PD-L1 are upregulated in HCC; MIAT promotes STAT3 by inhibiting miR-411-5p, increasing PD-L1 transcription. MIAT knockdown enhances T cell cytotoxicity, while miR-411-5p inhibition reverses STAT3 and PD-L1 reduction. The gene discussed is MIAT; the disease is hepatocellular carcinoma.