TUG1, upregulated by METTL3-mediated m6A, regulates PD-L1 and CD47 by sponging miR-141/miR-340 and interacting with YBX1; its knockdown inhibits tumor growth, enhances CD8+T/M1 macrophage infiltration, activates CD8+T via PD-L1, and boosts macrophage phagocytosis through CD47. This evidence concerns the gene CD8A and neoplasm.