lncRNA-GAS5 levels are reduced in PBMC-CD4+ T cells and tumor tissues compared to healthy controls and adjacent non-tumor tissues. Del/Del genotype increases lncRNA-GAS5 expression, lowers postoperative pain, and improves survival. lncRNA-GAS5 negatively correlates with IL-6, IL-17, and Th17 polarization index (RORγT/CD3). This evidence concerns the gene CD4 and neoplasm.