PPARA and hepatocellular carcinoma: For example, LINC01116 inhibits RAD18-mediated ubiquitination, stabilizing the EWSR1 protein and upregulating the expression of PPARA and long-chain fatty acid transporter FABP1, leading cancer cells to preferentially uptake linoleic acid and other long-chain fatty acids, resulting in T cell dysfunction and malignant progression of HCC.