Curcumin downregulates both H19 and HOTAIR in renal carcinoma and breast cancer cells. Curcumin affects EMT biomarkers including N-cadherin and E-cadherin levels. It reduces levels of N-cadherin and increases levels of E-cadherin. In vitro studies observed that curcumin decreases renal cancer cell migration and invasion by downregulating the expression level of HOTAIR (124). This evidence concerns the gene HOTAIR and breast carcinoma.