HSPA5 and osteosarcoma: Allicin activates osteosarcoma immunoreactivity and induces apoptosis through the CBR3-AS1/miR-145-5p/GRP78 molecular axis. Allicin triggers silencing CBR3-AS1 led to reduced Saos-2 activity, enhanced apoptosis, and activated mitophagy and endoplasmic reticulum stress.