cinnamaldehyde increased the curative effect of oxaliplatin by promoting apoptosis both in vitro and in vivo. Cinnamaldehyde and oxaliplatin synergistically reversed hypoxia-induced EMT and stemness of CRC cells and suppressed hypoxia-activated Wnt/β-catenin pathway synergistically. It inhibits P-glycoprotein expression through inhibition of STAT3 and AKT signaling to overcome drug resistance. The gene discussed is AKT1; the disease is colorectal carcinoma.