The macrophage (CD19- CD11c- CD68+ CD11b+) population showed fluctuations between the shNgp and shRen groups in the first 34 days post-HDI with a dramatic increase in shRen group and a moderate decrease in shNgp group when HCC developed and animals had to be sampled (Figure 5D). This evidence concerns the gene CD68 and hepatocellular carcinoma.