To identify genes that are upregulated in T lymphocytes during HCC development, we conducted a microarray analysis comparing CD4+ CD44+ and CD8+ CD44+ T cells isolated from HCC-bearing (genotype HCC: NRASG12V/c-Myc) mice with those isolated from HCC-free control animals (genotype C1: c-Myc; genotype C2: NRASG12V, Supplementary Figure S1A, Supplementary Figure S2A). Here, CD4 is linked to hepatocellular carcinoma.