on patients with advanced gastric cancer and VEGF-blocking antibody treatment, tumor-infiltrating lymphocytes (TILs) and PBMCs were compared regarding their expression of ICIs (PD-1, LAG3, CTLA-4, ICOS) and demonstrated a higher presence of ICIs on TILs than on PBMCs, highlighting the influence of T cell localization on the T cell phenotype (71). The gene discussed is ICOS; the disease is neoplasm.