Our team’s previous research has indicated that serum CHI3L1 levels increase with the progression of liver fibrosis in chronic hepatitis B (CHB) patients and outperform Hyaluronic acid (HA), type III procollagen III (PC-III), type IV collagen IV (IV-C), and laminin (LN) in diagnosing liver fibrosis (12). This evidence concerns the gene CHI3L1 and Hepatic fibrosis.