Several non-invasive serum markers and scores demonstrate potential for diagnosing liver fibrosis, including serum chitinase 3-like protein 1(CHI3L1), fibrosis index based on four factors (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and gamma glutamyl transferase-to-platelet ratio (GPR) (7). This evidence concerns the gene CHI3L1 and Hepatic fibrosis.