KRAS and neoplasm: As shown in Figure 6A, multiple tumor progression-inducing pathways were deactivated in the FOXN4 high group including the TGF-β signaling pathway and hypoxia, epithelial-mesenchymal transition (EMT), glycolysis, angiogenesis, and K-RAS signaling pathways, implying that FOXN4 exerts a tumor-suppressing function in LUAD by repressing these pathways.