Following LASSO regression analysis of the aforementioned 13 variables, we selected and retained 10 key variables: serum creatinine, chloride, CD4+ICOS+(%), CD19+PD-L1+(%), plasma sICOSL, CSF glucose levels, and clinical symptoms including fever, nausea and vomiting, headache, and cognitive impairment. This evidence concerns the gene ICOS and Cognitive impairment.