For example, consider a patient with the following characteristics: cognitive impairment (15 points), CD4+ICOS+ of 30% (22.5 points), CD19+PD-L1+ of 80% (27.5 points), plasma sICOSL of 500 ng/mL (40 points), and CSF glucose of 8 mmol/L (40 points). The gene discussed is ICOS; the disease is Cognitive impairment.