<h4>Background</h4>Migraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population.<h4>Methods</h4>The research analyzed specific genetic variations-TNF-α -308 G/A, TNF-α -857 C/T, TNF-α -238G/A, IL1B-3953 C/T, and IL1RN -2018T/C SNPs-within 212 migraine patients and 210 healthy controls. Here, IL1RN is linked to migraine disorder.