Additionally, the study observed a sex-specific difference regarding the TNF-α -857 C/T SNP among migraine patients.<h4>Conclusion</h4>Overall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B-3953 C/T SNP as a potential biomarker for migraine susceptibility. Here, IL1B is linked to migraine disorder.