FBXL4 and Periventricular cysts: There is no reported prenatal diagnostic of MTDPS13 linked to FBXL4. For the neonates died with FBXL4 variations, the review of prenatal phenotypes show periventricular cysts, periventricular echogenicity, ventriculomegaly, thin corpus callosum, mega cisterna magna, and large cavum (Saini et al., 2022), polyhydramnios and cerebellar atrophy (van Rij et al., 2016a).