FBXL4 and autosomal recessive disease: MTDPS13 is a rare autosomal recessive disease induced by biallelic mutations in the F-box and leucine-rich repeat (LRR) protein 4 gene (FBXL4) (Gai et al., 2013), characterized by increased mitochondrial autophagy and mitochondrial DNA (mtDNA) depletion in FBXL4 knockout mice and patient fibroblasts (Alsina et al., 2020).