TRPM2 and brain ischemia: This observation is consistent with several recent studies by our group, demonstrating male-specific neuroprotection in TRPM2 KO or inhibition following models of cerebral ischemia, both focal (Jia et al., 2011; Shimizu et al., 2016; Shimizu et al., 2013) and global (Nakayama et al., 2013; Dietz et al., 2020; Shimizu et al., 2016; Dietz et al., 2021).