Interestingly, we recently demonstrated that delayed inhibition of TRPM2 channels following global cerebral ischemia enhanced cognitive recovery in both male and female animals, indicating a chronic activity of TRPM2 channels that contributes to secondary injury in both sexes, as indicated by improved neurobehavioral memory function and enhanced hippocampal synaptic plasticity (Dietz et al., 2020). This evidence concerns the gene TRPM2 and Cerebral ischemia.