RBFOX3 and Leber hereditary optic neuropathy: Pathway enrichment analysis showed a significant enrichment for mitochondrial genes in both Olig2+ (false discovery rate [FDR] <0.001) and NeuN+ nuclei (FDR <0.001), and specifically genes related to Leber’s hereditary optic neuropathy (LHON) in rs10191329AA donors (Olig2: FDR = 0.019; NeuN: FDR = 0.093; Figures 4F, 4H, S3F, S3G, and Table S1).