KLK3 and posterior cortical atrophy: Patients are at an high risk of PCa (HRPCa) if their total PSA (TPSA) exceeds 10, or if their TPSA falls between 4 and 10 with free PSA (fPSA) constituting less than 25% of the TPSA (Catalona et al., 1994; 1998).