For instance, sclerostin has been shown to regulate lacuna size via the LRP4/5/6 pathway (Kogawa et al., 2013; Kogawa et al., 2018), while alterations in TGF-β and parathyroid hormone (PTH) signaling have been associated with disrupted LCS remodeling in T2DM (Gardinier et al., 2016; Picke et al., 2019). Here, PTH is linked to type 2 diabetes mellitus.