These include the polycomb proteins, e.g., BMI‐1 or SUZ12, and EZH2 (Enhancer of Zeste Homolog 2), all reported in most skin cancers inclusive of melanoma.[33, 34] From Qendro and and co‐workers research, they confirm histone H2A1B, annexin A1, vimentin, nestin, dipeptidyl peptidase IV and fibronectin as promising targets for the differentiation and diagnosis of melanoma‐based malignancies. The gene discussed is EZH2; the disease is melanoma.