EZH2 and skin neoplasm: These include the polycomb proteins, e.g., BMI‐1 or SUZ12, and EZH2 (Enhancer of Zeste Homolog 2), all reported in most skin cancers inclusive of melanoma.[33, 34] From Qendro and and co‐workers research, they confirm histone H2A1B, annexin A1, vimentin, nestin, dipeptidyl peptidase IV and fibronectin as promising targets for the differentiation and diagnosis of melanoma‐based malignancies.