CDKN2A and neoplasm: Recently, Nikolouzakis et al. provided interesting insights into other changes occurring at the higher molecular level, including telomere length, telomerase activity and/or the epigenetic markers mentioned formerly.[52] Some of the involved genes have active roles in the deregulation of the cell cycle, e.g., CDKN2A, activation of proto‐oncogenes, e.g., MYCL2, or silencing of genes used to suppress tumor formation, e.g., p14‐ARK, DUSP2 etc., through altered methylation status (Figure4).