ELN and cancer: Some of the most significant biomarkers and indeed most studied included collagen, elastin, triolein, keratin, ceramide, melanin, composition of water and indeed the biophysical and morphological changes observed in the nucleus.[53, 61, 62, 63, 64] Silveira Jr et al. recounted the critical function of actin in growth and organization of carcinoma cells and most explicitly, the expression as a marker of cancer invasiveness.[53] Fendel and Schrader and Feng et al.