Preliminary studies have shown that targeting GLO1 by small molecule inhibitors such as S-p-bromobenzylglutathione cyclopentyl diester (BBGC) significantly inhibits the growth and induces apoptosis of leukemia and other tumor cells, while reversing the resistance of cancer cells to chemotherapeutic drugs (103, 144, 152–154). This evidence concerns the gene GLO1 and leukemia.