Moreover, MG derivative MG-H1 down-regulates PD-L1 expression in tumor cells in metastatic prostate cancer (mPCa), whereas high expression of GLO1 limits the accumulation of MG-H1 and maintains the expression of PD-L1, which inhibits CD8+ T cell function and promotes immune escape in mPCa. The gene discussed is CD274; the disease is metastatic prostate carcinoma.