BCL2 and breast carcinoma: It has been shown that proapoptotic genes suchas Bax and Bcl-2 are expressed when P53 is stabilized by azurin/p28and enters the nucleus.25,26 MCF-7 breast cancercells treated with 53 μM azurin for 72 h showed 20% cell survivalafter treatment (Figure 1).25 Similarly, 44% cell death was observedin ZR-75-1 breast cancer cells after 72 h of treatment with 100 μMp28.27 Yamada et al. reported that azurinand p28 can effectively stop the formation of tumors in mouse models,such as Dalton’s lymphoma mice, 4T1 breast tumor mice, andMCF-7 human breast cancer xenograft on mice.27−29