In cancer treatment,heat shock protein (HSP) gp96, a molecular chaperone found in cancercell membranes, is often targeted.38,39 The gp96 N-terminalhelix–loop–helix region is specifically recognized bythe peptide p37 (LNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY),which can interfere with the intramolecular helix–helix interaction,limit conformational variations of gp96 and disrupting its chaperoningfunction.39,40. Here, HSP90B1 is linked to cancer.