A 9-amino acid α-helical structure that directsand binds lunasin to the core histone proteins comes right beforethis sequence, as does the Arg-Gly-Asp (RGD) motif, which binds tothe extracellular matrix and helps the peptide penetrate cells.84 This peptide has also been found to have beneficialeffects on neurodegenerative illnesses such as amyotrophic lateralsclerosis (ALS) and Alzheimer’s disease (AD).85 Here, H2BC12L is linked to Alzheimer disease.