Regarding THBS2, several studies demonstrated that it can increase the expression of MMP13 and MMP9, further activating integrin αvβ3/FAK/Akt/NF-κB and integrin αvβ3/phospholipase C (PLC)/protein kinase C (PKC)/c-Src/NF-κB signaling pathway, respectively, which ultimately facilitating lung cancer and osteosarcoma metastasis (Liu et al., 2020; Liu et al., 2018). The gene discussed is NFKB1; the disease is osteosarcoma.