Several studies have shown that in GC, the cooperation of integrin β1 in MGC-803 cells and galectin-1 (Gal-1) derived from CAFs increases the expression level of glioma-associated oncogene 1 (Gli1), activates hedgehog (Hh) signaling pathway, and facilitates the EMT and GC invasion (Chong et al., 2016; He et al., 2014). The gene discussed is LGALS1; the disease is gastric cancer.