CAF-secreted IL-32 with an RGD motif binds to integrin β3 on BC cell surface and activates downstream p38 MAPK signaling pathway, thus increasing the expression of several EMT markers including FN, N-cadherin, and vimentin (Jang & Beningo, 2019; Wen et al., 2019). Here, FN1 is linked to breast cancer.