Additionally, in colon and pancreatic tumors, integrin αvβ3 assists αvβ1 to produce parallel fibronectin alignment that mediates communication between αvβ1 on tumor cells and assembled fibronectin on the CAF surface, thus triggering tumor migration in a specific direction (Jang & Beningo, 2019; Zeltz et al., 2020). This evidence concerns the gene FN1 and neoplasm.