PIK3CA and esophageal squamous cell carcinoma: With respect to MFGE8, Liu et al. (2023a) found that it can aggravate angiogenesis, metastasis, and progression in esophageal squamous cell carcinoma (ESCC) via binding to integrin αvβ3 and integrin αvβ5 in HUVECs and phosphorylating PI3K/Akt/STAT3 and Erk/Akt signaling pathway in in vitro study.