Furthermore, it was demonstrated that cysteine-rich 61 (Cyr61), preferentially expressed in adipose-derived stem cells (ADSCs), combined with its functional receptor integrin αvβ5 to activate downstream FAK/ NF-κB signaling and FAK/HIF-α/STAT3/MMP-2 signaling, thereby promoting tumor growth and metastasis, especially in CRC progression (Liang et al., 2021). This evidence concerns the gene PTK2 and neoplasm.