CD4 and neoplasm: In addition, Jiang et al. found that VS-4718, a FAK inhibitor, can facilitate the infiltration of CD8+ CTL, decrease the numbers of immunosuppressive cells, such as tumor-infiltrating myeloid-derived suppressor cells, CD206+ tumor-associated macrophages, and CD4+FOXP3+ Tregs, and improve the response to anti-PD1 and gemcitabine in the p48-Cre/LSL-KrasG12D/p53Flox/+ (KPC) PDAC mouse model (Jiang et al., 2016).