When the blood-brain barrier is disrupted by a tumor, NK cells enter the glioma tumor tissue and interact with glioblastoma stem cells, inducing both the release and production of TGF-β by GSCs in an intercellular crosstalk-dependent manner, in which the interaction between integrin αv on GSCs and CD9 and CD103 on NK cells is necessary. Here, TGFB1 is linked to neoplasm.