ICAM1 and melanoma: However, multiple tumors, such as melanoma, oral squamous cell carcinoma, and colorectal cancer, express intracellular adhesion molecule-1 (ICAM-1) rather than integrin, and endothelial cells also express ICAM-1; consequently, leukocytes with integrin αLβ2 (LFA-1) act as a bridge between tumor and endothelial cells (Liang et al., 2007; Sokeland & Schumacher, 2019; Usami et al., 2013).