FN1 and colonic neoplasm: FN not only contributes to matrix stiffness, but also engages in directional migration, invasion, and metastasis of prostate, pancreatic, and colon tumors along FN matrices and protrusion of CAFs (Attieh et al., 2017; Erdogan et al., 2017; Jang & Beningo, 2019; Miyazaki et al., 2020; Zeltz et al., 2020).