Integrin αvβ1 on CAFs participates in the fibrillar fibronectin assembly of CAFs via PDGFRα, and in myosin light chain 2 (MLC2) contractility and traction forces, which then induces directional mobility of tumor cells (Attieh et al., 2017; Erdogan et al., 2017; Jang & Beningo, 2019; Zeltz et al., 2020). Here, FN1 is linked to neoplasm.