Similarly, T-786C polymorphism(rs2070744) in the promoter region of NOS3 has been reported to bestrongly linked to an increased risk of MetS in Russian patients with SCZ [49].Further study related to nitric oxide synthase 1 articulating protein (NOS1AP), which regulates NOS3, has confirmedthe associations between 2 nucleotide polymorphisms (rs12143842 and rs10494366)and the risk of MetS in Russian patients [50]. Here, NOS1AP is linked to metabolic syndrome.