Skin biopsy, nailfold visualization, capillaroscopy, laser Doppler, thermography for Raynaud’s, ANA antibodies, and specific antibodies like anti-topoisomerase I (ATA), ACA, anti-RNA polymerase III (ARA), anti-Th/To, and anti-U3 RNP are the several diagnostic tests where the presence of SSc have to be suspected [20,63]. This evidence concerns the gene ATM and systemic sclerosis.