According to the validated international diagnostic criteria proposed by Nishimura et al., a definitive diagnosis of TAFRO syndrome requires the presence of all four core clinical features: thrombocytopenia (pre-treatment platelet count ≤100 × 103/μL), anasarca (pleural effusion, ascites, or subcutaneous edema), fever or hyperinflammatory status (body temperature ≥37.5°C of unknown origin or CRP ≥2.0 mg/dL), and organomegaly (small-volume lymphadenopathy in two or more regions, hepatomegaly, or splenomegaly) [11]. This evidence concerns the gene CRP and Pleural effusion.