Recent research has increasinglyfocused on calcium abnormalities, including impaired calcium release,calcium-dependent inactivation, and altered excitation-contraction coupling.These have been identified as core features in many LQTS subtypes, such ascalmodulinopathy, triadin knockout syndrome (TKOS), Jervell and Lange-Nielsensyndrome (JLNS), and Andersen-Tawil syndrome (ATS). This evidence concerns the gene TRDN and Andersen-Tawil syndrome.