In addition, both testosterone replacement therapy andtreatment with growth hormone analogues promote muscle growth and fat loss.Although active counselling of patients with obesity or overweight with AF is aneffective intervention for facilitating appropriate weight loss, the greatestbenefits of weight loss depend on the ability to preserve muscle tissues.Therefore, optimising patient’s body composition by increasing lean body mass anddecreasing fat weight is important, a strategy that is more effective than simplytargeting BMI reduction [46]. This evidence concerns the gene GH1 and obesity disorder.