AGTR1 and hypertensive disorder: Additionally, chronicC21-induced AT2R activation initiated and sustained the translocation of AT2R tothe apical plasma membrane (APM) of renal proximal tubular cells (RPTCs).Importantly, the systemic or intrarenal administration of C21 was found to besuccessful at lowering BP even without simultaneous inhibition of AT1R,confirming its autonomous ability to reduce hypertension [91].