AGTR1 and hypertensive disorder: With regard to thelocal mechanism, the RAS has been linked to hypertension in the cardiovascularsystem, dyslipidemia in adipocyte metabolism, memory and cognitive functions inthe central nervous system, glomerulosclerosis and tubulointerstitial fibrosis inthe kidney, and mucosal barrier integrity in the gastrointestinal tract [7].Several anti-hypertensive drugs that target the RAS are in use, includingACE-inhibitors (ACEi) and AT1R blockers (ARB).