Therefore, monitoringinflammation-related biomarkers, such as homocysteine levels, may be instrumentalin predicting the severity and treatment outcomes of AF patients [58].Some studies predict that adding the inflammatory factors IL-6and CRP to the CHA2DS2-VASc risk score can improve its prognostic accuracy;however, excessive use of these inflammatory indicators in risk assessment canlead to incorrect anticoagulant use [39]. This evidence concerns the gene CRP and atrial fibrillation.