Among the antibodiesproduced against H. pylori by the human body, antibodies targetingH. pylori Vac A are recognized as the only causal factor linked to anincreased risk of stroke, with CRP possibly facilitating this relationship.Therefore, targeting the CRP signaling pathway could lower the risk of stroke inpatients infected with Vac A-positive strains of H. pylori [99, 100, 101].Meanwhile, further research has indicated that eradicating H. pylorimight decrease stroke risk in AF patients [99]. This evidence concerns the gene CRP and atrial fibrillation.