However, the sheer force and trauma caused by needle injection are more damaging to molecules.10 NFJIs have been used for animal vaccinations, human vaccinations, administration of insulin, anesthetic, and even botulinum toxin for palmar hyperhidrosis.11 Multiple studies have confirmed that even the most sensitive substances, such as DNA plasmids, mRNA, liposomes, and nanosuspensions, can be successfully propelled across the dermis with maintenance of their physical and functional properties. Here, INS is linked to Hyperhidrosis.