However, a study has recently demonstrated that the PCIF1-mediated installment of 5′-cap m6Am increases susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by stabilizing mRNA which leads to sustained transcription and translation of genes encoding the coronavirus receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) (Wang L. et al., 2023). Here, ACE2 is linked to COVID-19.