Notably, specific SLC2A9 variants, which are more frequent in Non-Hispanic Whites, significantly elevate blood uric acid levels through enhanced uric acid reabsorption (25); (2) Pathophysiological heterogeneity in osteoporosis, including racial differences in vitamin D metabolism, as evidenced by the notably lower prevalence of vitamin D deficiency in Non-Hispanic Whites compared to other racial groups (26); and (3) Potential limitations in statistical power for smaller subgroup analyses. This evidence concerns the gene SLC2A9 and vitamin D deficiency.