As shown in Figure 3D, these clusters correspond to four major research directions: Acute exacerbation (red, #0), Bronchoalveolar lavage protein profile (light green, #2), Rheumatoid arthritis associated interstitial lung disease (CTD-ILDs; dark green, #3), and Cold-inducible RNA-binding protein (CIRBP; blue, #5).Acute exacerbation is a critical research direction in pulmonary fibrosis, often associated with poorer prognosis. The gene discussed is CIRBP; the disease is rheumatoid arthritis-associated interstitial lung disease.