In experiments targeting a mouse model of hearing loss and HEI-OC1 cells, resveratrol was found to upregulate miR-455-5p, which in turn downregulated phosphatase and tensin homolog (PTEN) and activated the phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) signaling pathway in order to counteract cisplatin ototoxicity (Liu et al., 2021). The gene discussed is PTEN; the disease is hearing loss disorder.