Notably, one of Yu’s studies identified glutathione peroxidase-1 (GPx1) as a key regulator of epithelial-mesenchymal transition (EMT) and chemoresistance through modulation of the AKT/GSK3β/Snail signaling axis in PC, suggesting that GPx1 may serve as a potential predictive biomarker for GEM treatment in PC patients (Meng et al., 2018). This evidence concerns the gene AKT1 and pachyonychia congenita.