A controlled study based on 25 patients within the age range of 40–82 years indicated that the risk of thrombosis would decrease when patients were exposed to TNF-α blocker drugs.And it is consistent with the analysis results of a study involving more than 40 rheumatoid arthritis(RA) patients (Manfredi et al., 2016). The gene discussed is TNF; the disease is rheumatoid arthritis.