ADIPOQ and endothelial dysfunction: In addition, adiponectin, as an insulin-sensitizing Hormone, can significantly reduce blood triglyceride and LDL levels, however, its levels were found to be downregulated after TNF-alpha inhibitor treatment, which leads to disruption of lipid metabolism, which exacerbates endothelial dysfunction and ultimately causing thrombosis (Campanati et al., 2015).