HDAC3 and renal fibrosis: In addition, Baihai Jiao, et al. reported that inhibition of STAT6 reduced M2 macrophage polarization and attenuated renal fibrosis (Czimmerer et al., 2018; Jiao et al., 2021).Moreover, the precise mechanisms linking HDAC3 with effects on RIPK1 expression and necroptosis need to be explored in better detail to determine how to best suppress this pathway in the clinical context.