The COL4A1 and COL4A2 had the most significant association with tumor grade (AUC = 0.822 and 0.820 in G2 vs G3 and G4; AUC = 0.863 and 0.834 in G3 vs G4), followed by COL4A3 and COL4A4 (AUC = 0.539 and 0.585 in G2 vs G3 and G4; AUC = 0.677 and 0.753 in G3 vs G4). Here, COL4A4 is linked to neoplasm.