Our novel finding in glioma reveals that HMGA2 is regulated by COL4As, particularly COL4A1, although this regulatory relationship has been previously reported in other malignanciesincluding esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), hepatocellular carcinoma (LIHC), and colon adenocarcinoma (COAD) (Tang et al., 2024). This evidence concerns the gene HMGA2 and colon adenocarcinoma.