For another, based on the results from Figure 10, two immunomodulators were correlated with COL4As and HMGA2, including immunostimulator TNFRSF18 and immunoinhibitor CD274, which are also known as PDL-1 and GITR and have important effects on prognosis of glioma (Li Y. et al., 2020; Li et al., 2014; Zhou et al., 2021). The gene discussed is TNFRSF18; the disease is central nervous system cancer.