Our novel finding in glioma reveals that HMGA2 is regulated by COL4As, particularly COL4A1, although this regulatory relationship has been previously reported in other malignanciesincluding esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), hepatocellular carcinoma (LIHC), and colon adenocarcinoma (COAD) (Tang et al., 2024). Here, COL4A1 is linked to central nervous system cancer.