Alterations in the COL4A3, COL4A4 and COL4A5 genes are associated with glomerular basement membrane-related diseases, such as autosomal recessive Alport syndrome (Storey et al., 2013; Hudson et al., 2003), familial focal segmental glomerulosclerosis (Andrew et al., 2014), and thin basement membrane nephropathy (Wang et al., 2004). This evidence concerns the gene COL4A3 and autosomal recessive Alport syndrome.