Even so, by establishing the prognostic model in multivariate Cox regression analysis, we found that although none of the COL4A family members can function as the independent prognostic factors for glioma patients’ survival, the risk scores of this model still positively related to the expression of COL4A1 and COL4A2, and has a negative corelation with COL4A3 and COL4A4 (Supplementary Figure S1C). Here, COL4A3 is linked to central nervous system cancer.