Compared to the model group, the expression levels of p-STAT3/STAT3 proteins in the tumor tissues of the Nolvadex, RRTS-H, and RRTS-M groups were significantly reduced (P < 0.01), while those in the RRTS-L group was notably reduced (P < 0.05; Figures 4A–C). Here, STAT3 is linked to neoplasm.