In a recent study, Dectin-1 was upregulated in the livers of HFD-induced NAFLD mice and human NASH patients; genetic knockout or pharmacologic blockade of Dectin-1 markedly attenuated steatosis, inflammation and fibrosis in NAFLD models (Wang et al., 2023). The gene discussed is CLEC7A; the disease is metabolic dysfunction-associated steatohepatitis.