HAND2 and breast cancer: Based on bioinformatic predictions, experimental data, and literature review, we constructed a regulatory network illustrating potential interactions among the investigated lncRNAs (ADAMTS9-AS2, HAND2-AS1, HOTAIRM1, MEG3), miRNAs (miR-17-5p, miR-106a-5p, and others), the key DNA methyltransferase DNMT1, and genes associated with EMT and metastasis (including TCF7L2, VIM, VEGFA, ZEB1, CDH1, PTEN, and TGFB1) in the context of BC (Figure 9).