IL6 and rheumatoid arthritis: Accordingly, AMPK activation in RA models showed enhanced inflammatory response via reduction of IL-6, modulation of immune response, and attenuation of cartilage damage which could be linked to subsequence inhibition of Hedgehog pathway, responsible for FLS migration and pannus formation (Guma et al. 2015; Li et al. 2015a, b; Wang et al. 2022).