Angiogenesis is a key factor in tumor development and metastasis because the formation of new blood vessels enhances the delivery of nutrients and oxygen to rapidly proliferating cells.373 In EBVaGC, hypoxia-induced EBV-encoded circular RNA LMP2A (EBV-circLMP2A) promotes angiogenesis through the KHSRP/VHL/HIF-1α/VEGFA pathway.373 EBV-miRNA-BART12 inhibits tubulin polymerization-promoting protein 1 (TPPP1), suppressing α-tubulin acetylation, promoting microtubule dynamic assembly and acetylation, and activating EMT. Here, HIF1A is linked to neoplasm.