PDLIM7 and neoplasm: EBV plays a crucial role in regulating B-cell metabolism and cell cycle progression through the interaction between EBNA2 and EBF1 during EBV infection.625 LMP1, a direct target gene of EBNA2, acts as a significant metabolic regulator in many EBV-related tumor cells by enhancing aerobic glycolysis.626 Additionally, EBV-infected B cells induce the expression of monocarboxylate transporter 1 (MCT1) and monocarboxylate transporter 4 (MCT4) through EBNA2 and LMP1, respectively, which are crucial for B-cell proliferation.