Eleven polymorphisms, rs4759276, rs4759275, rs1385526, rs1799737, rs1466535, rs10876964, rs4759045, rs10876965, rs11172113, rs4367982, rs4759277 of the LRP1 gene showed significant results for migraine with p-values below the multiple hypothesis correction threshold of 3.66 × 10–6 (0.05/13635, Supplementary material 11). Here, LRP1 is linked to migraine disorder.