As Bonferroni-correction is known to filter positive findings in favor to control type 1 errors [61–63], some genes, such as EFNB2, CBR3, TEK, KCNMA1, HTR7 with nominally significant SNPs and connection to migraine or its characteristics [64–68], may (also) have genetically determined changes in their gene expression. Here, EFNB2 is linked to migraine disorder.