POT1 and cancer: Given the emerging phenotype of this recently described cancer predisposition syndrome and the possibility of increased identification of POT1 GPVs via large gene panels, the clinical guideline group of the CanGene-CanVar project, in collaboration with representatives from the UK Cancer Genetics Group (UKCGG) and a small working group of experts in cancers associated with POT1-TPDS, held two virtual meetings with the aim to address three main areas: