POT1 and cancer: As the risk of the development of cutaneous melanoma is multifactorial, the consensus group agreed that taking into consideration various risk factors (eg, prior melanoma, skin type and colour, hair colour, mole number and morphology, sun exposure, degree of sunburn as a child, personal and family history of cancer), as well as detailed phenotyping of individuals with POT1 GPVs would be beneficial in guiding further surveillance decision-making within a dermatology clinic.