IL27 and neoplasm: However, there was no difference in antitumor efficacy between the CAL-101 combined with VVL-TD-mIL-27 group and the VVL-TD-mIL-27 group, which may be due to the fact that, OV therapy exerts antitumor effects through multiple mechanisms, and although the increase in viral copy number in tumor tissues enhanced the oncolysis, the IL-27-armed virus also elicited a strong antiviral immune response.