IL27 and neoplasm: In the present study, we armed the virus with human or murine IL-27 to construct VVLΔTKΔN1LΔA41L-h/mIL-27 (hereafter referred to as VVL-TD-h/mIL-27) and proved that VVL-TD-mIL-27 has a strong antitumor effect, which can achieve up to 100% tumor clearance and the induction of long-term antitumor immune responses.