CD8A and neoplasm: IL-27 is a new member of the IL-12 family, which was discovered and named in 2002 and has potent antitumor activity.19 20 IL-27 exerts its antitumor effects through a variety of mechanisms, including enhancing the survival of tumor antigen-specific CD8+ T cells,21 promoting the activation of NK cells,22 inhibiting angiogenesis,23 increasing M1-polarized tumor-associated macrophages,24 and directly suppressing tumor cells proliferation.25