CCN4 and alcoholic hepatitis: As shown in Figure 1C, Wnt ligands (Wnt5a, Wnt5b, Wnt7b), receptors (FZD4 and -5, LRP5 and -6), DVL1, and transcriptional regulators (TCF7, β1-catenin) were down-regulated, whereas receptors (FZD-1, -2, -3, -6, and -7), LEF1, Axin2, the transcriptional regulator TCF4, and three Wnt-inducible secreted proteins (WISP1 to -3/CCN4 to -6) were up-regulated in the livers of patients with alcoholic hepatitis (AH).